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Defunctionalized Lobeline Analogues: Structure–Activity of Novel Ligands for the Vesicular Monoamine Transporter

(−)-Lobeline (2R,6S,10S; 1a), an antagonist at nicotinic acetylcholine receptors (nAChRs), inhibits the neurochemical and behavioral effects of methamphetamine and inhibits dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) function. VMAT2 is a target for the development of treat...

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Autors principals: Zheng, Guangrong, Dwoskin, Linda P., Deaciuc, Agripina G., Norrholm, Seth D., Crooks, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617589/
https://ncbi.nlm.nih.gov/pubmed/16107155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0501228
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