Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters

Vescular monoamine transporter-2 (VMAT2) is a viable target for development of pharmacotherapies for psychostimulant abuse. Lobeline (1) is a potent antagonist at α4β2* nicotinic acetylcholine receptors, has moderate affinity (K(i)=5.46 μM) for VMAT2, and is being investigated currently as a clinica...

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Bibliografiske detaljer
Main Authors: Hojahmat, Marhaba, Horton, David B., Norrholm, Seth D., Miller, Dennis K., Grinevich, Vladimir P., Deaciuc, Agripina Gabriela, Dwoskin, Linda P., Crooks, Peter A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726004/
https://ncbi.nlm.nih.gov/pubmed/20036131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.12.002
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