Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters

Vescular monoamine transporter-2 (VMAT2) is a viable target for development of pharmacotherapies for psychostimulant abuse. Lobeline (1) is a potent antagonist at α4β2* nicotinic acetylcholine receptors, has moderate affinity (K(i)=5.46 μM) for VMAT2, and is being investigated currently as a clinica...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Hojahmat, Marhaba, Horton, David B., Norrholm, Seth D., Miller, Dennis K., Grinevich, Vladimir P., Deaciuc, Agripina Gabriela, Dwoskin, Linda P., Crooks, Peter A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726004/
https://ncbi.nlm.nih.gov/pubmed/20036131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.12.002
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk