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Lobelane analogues as novel ligands for the vesicular monoamine transporter-2

A series of lobelane analogues has been synthesized and their structure–activity relationships at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent analogues in this series were the cis-2,6-piperidino analogues, 25b, 27b, 28b, and 30b, with K(i) values ranging from 4...

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Autori principali: Zheng, Guangrong, Dwoskin, Linda P., Deaciuc, Agripina G., Zhu, Jun, Jones, Marlon D., Crooks, Peter A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593046/
https://ncbi.nlm.nih.gov/pubmed/15911306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2005.04.013
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