Lobelane Inhibits Methamphetamine-Evoked Dopamine Release via Inhibition of the Vesicular Monoamine Transporter-2

Lobeline is currently being evaluated in clinical trials as a methamphetamine abuse treatment. Lobeline interacts with nicotinic receptor subtypes, dopamine transporters (DATs), and vesicular monoamine transporters (VMAT2s). Methamphetamine inhibits VMAT2 and promotes dopamine (DA) release from syna...

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Bibliografiset tiedot
Päätekijät: Nickell, Justin R., Krishnamurthy, Sairam, Norrholm, Seth, Deaciuc, Gabriela, Siripurapu, Kiran B., Zheng, Guangrong, Crooks, Peter A., Dwoskin, Linda P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2010
Aiheet:
Neuropharmacology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812121/
https://ncbi.nlm.nih.gov/pubmed/19855096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.160275
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