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Novel N-1,2-Dihydroxypropyl Analogs of Lobelane Inhibit Vesicular Monoamine Transporter-2 Function and Methamphetamine-Evoked Dopamine Release

Lobelane, a chemically defunctionalized saturated analog of lobeline, has increased selectivity for the vesicular monoamine transporter 2 (VMAT2) compared with the parent compound. Lobelane inhibits methamphetamine-evoked dopamine (DA) release and decreases methamphetamine self-administration. Unfor...

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Detalhes bibliográficos
Main Authors: Horton, David B., Siripurapu, Kiran B., Zheng, Guangrong, Crooks, Peter A., Dwoskin, Linda P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186287/
https://ncbi.nlm.nih.gov/pubmed/21778282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.184770
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