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Synthesis and Evaluation of a Series of Homologues of Lobelane at the Vesicular Monoamine Transporter-2
A series of lobelane homologues has been synthesized and evaluated for their [(3)H]DTBZ binding affinity at the vesicular monoamine transporter-2 (VMAT2). The structure-activity relationships (SAR) indicate that for retention of binding affinity at VMAT2, the lengths of the methylene linkers should...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2008
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3652799/ https://ncbi.nlm.nih.gov/pubmed/18976906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.10.042 |
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