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Synthesis and Evaluation of a Series of Homologues of Lobelane at the Vesicular Monoamine Transporter-2

A series of lobelane homologues has been synthesized and evaluated for their [(3)H]DTBZ binding affinity at the vesicular monoamine transporter-2 (VMAT2). The structure-activity relationships (SAR) indicate that for retention of binding affinity at VMAT2, the lengths of the methylene linkers should...

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Main Authors: Zheng, Guangrong, Dwoskin, Linda P., Deaciuc, Agripina G., Crooks, Peter A.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652799/
https://ncbi.nlm.nih.gov/pubmed/18976906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.10.042
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