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β-hairpin-mediated nucleation of polyglutamine amyloid formation
The conformational preferences of polyglutamine (polyQ) sequences are of major interest because of their central importance in the expanded CAG repeat diseases that include Huntington’s disease (HD). Here we explore the response of various biophysical parameters to the introduction of β-hairpin moti...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3602386/ https://ncbi.nlm.nih.gov/pubmed/23353826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.01.016 |
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