Backbone engineering within a latent β-hairpin structure to design inhibitors of polyglutamine amyloid formation

Candidates for the toxic molecular species in the expanded polyglutamine (polyQ) repeat diseases range from various types of aggregates to “misfolded” monomers. One way to vet these candidates is to develop mutants that restrict conformational landscapes. Previously we inserted two self-complementar...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Kar, Karunakar, Baker, Matthew A., Lengyel, George A., Hoop, Cody L., Kodali, Ravindra, Byeon, In-Ja, Horne, W. Seth, van der Wel, Patrick C.A., Wetzel, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286556/
https://ncbi.nlm.nih.gov/pubmed/27986569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.12.010
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