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Backbone engineering within a latent β-hairpin structure to design inhibitors of polyglutamine amyloid formation
Candidates for the toxic molecular species in the expanded polyglutamine (polyQ) repeat diseases range from various types of aggregates to “misfolded” monomers. One way to vet these candidates is to develop mutants that restrict conformational landscapes. Previously we inserted two self-complementar...
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| Udgivet i: | J Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5286556/ https://ncbi.nlm.nih.gov/pubmed/27986569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.12.010 |
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