β-hairpin-mediated nucleation of polyglutamine amyloid formation

The conformational preferences of polyglutamine (polyQ) sequences are of major interest because of their central importance in the expanded CAG repeat diseases that include Huntington’s disease (HD). Here we explore the response of various biophysical parameters to the introduction of β-hairpin moti...

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Detalhes bibliográficos
Main Authors: Kar, Karunakar, Hoop, Cody L., Drombosky, Kenneth W., Baker, Matthew A., Kodali, Ravindra, Arduini, Irene, van der Wel, Patrick C. A., Horne, W. Seth, Wetzel, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602386/
https://ncbi.nlm.nih.gov/pubmed/23353826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.01.016
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