β-hairpin-mediated nucleation of polyglutamine amyloid formation

The conformational preferences of polyglutamine (polyQ) sequences are of major interest because of their central importance in the expanded CAG repeat diseases that include Huntington’s disease (HD). Here we explore the response of various biophysical parameters to the introduction of β-hairpin moti...

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Detaylı Bibliyografya
Asıl Yazarlar: Kar, Karunakar, Hoop, Cody L., Drombosky, Kenneth W., Baker, Matthew A., Kodali, Ravindra, Arduini, Irene, van der Wel, Patrick C. A., Horne, W. Seth, Wetzel, Ronald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602386/
https://ncbi.nlm.nih.gov/pubmed/23353826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.01.016
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