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Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core
Polyglutamine expansion within the exon1 of huntingtin leads to protein misfolding, aggregation, and cytotoxicity in Huntington’s disease. This incurable neurodegenerative disease is the most prevalent member of a family of CAG repeat expansion disorders. Although mature exon1 fibrils are viable can...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4760812/ https://ncbi.nlm.nih.gov/pubmed/26831073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521933113 |
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