Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core

Polyglutamine expansion within the exon1 of huntingtin leads to protein misfolding, aggregation, and cytotoxicity in Huntington’s disease. This incurable neurodegenerative disease is the most prevalent member of a family of CAG repeat expansion disorders. Although mature exon1 fibrils are viable can...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Hoop, Cody L., Lin, Hsiang-Kai, Kar, Karunakar, Magyarfalvi, Gábor, Lamley, Jonathan M., Boatz, Jennifer C., Mandal, Abhishek, Lewandowski, Józef R., Wetzel, Ronald, van der Wel, Patrick C. A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760812/
https://ncbi.nlm.nih.gov/pubmed/26831073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521933113
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