Backbone engineering within a latent β-hairpin structure to design inhibitors of polyglutamine amyloid formation

Candidates for the toxic molecular species in the expanded polyglutamine (polyQ) repeat diseases range from various types of aggregates to “misfolded” monomers. One way to vet these candidates is to develop mutants that restrict conformational landscapes. Previously we inserted two self-complementar...

Full description

Saved in:
Bibliographic Details
Published in:J Mol Biol
Main Authors: Kar, Karunakar, Baker, Matthew A., Lengyel, George A., Hoop, Cody L., Kodali, Ravindra, Byeon, In-Ja, Horne, W. Seth, van der Wel, Patrick C.A., Wetzel, Ronald
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286556/
https://ncbi.nlm.nih.gov/pubmed/27986569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.12.010
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items