Improving the Affinity of SL0101 for RSK Using Structure-Based Design

[Image: see text] Enhanced activity of the Ser/Thr protein kinase, RSK, is associated with transformation and metastasis, which suggests that RSK is an attractive drug target. The natural product SL0101 (kaempferol 3-O-(3″,4″-di-O-acetyl-α-l-rhamnopyranoside)) has been shown to be an RSK selective i...

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Detalhes bibliográficos
Main Authors: Mrozowski, Roman M., Vemula, Rajender, Wu, Bulan, Zhang, Qi, Schroeder, Benjamin R., Hilinski, Michael K., Clark, David E., Hecht, Sidney M., O’Doherty, George A., Lannigan, Deborah A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601785/
https://ncbi.nlm.nih.gov/pubmed/23519677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300298v
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