Enhanced 5-methylcytosine detection in single-molecule, real-time sequencing via Tet1 oxidation

BACKGROUND: DNA methylation serves as an important epigenetic mark in both eukaryotic and prokaryotic organisms. In eukaryotes, the most common epigenetic mark is 5-methylcytosine, whereas prokaryotes can have 6-methyladenine, 4-methylcytosine, or 5-methylcytosine. Single-molecule, real-time sequenc...

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Detalhes bibliográficos
Main Authors: Clark, Tyson A, Lu, Xingyu, Luong, Khai, Dai, Qing, Boitano, Matthew, Turner, Stephen W, He, Chuan, Korlach, Jonas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598637/
https://ncbi.nlm.nih.gov/pubmed/23339471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-11-4
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