Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing

DNA methylation is the most common form of DNA modification in prokaryotic and eukaryotic genomes. We have applied the method of single-molecule, real-time (SMRT®) DNA sequencing that is capable of direct detection of modified bases at single-nucleotide resolution to characterize the specificity of...

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Autors principals: Clark, Tyson A., Murray, Iain A., Morgan, Richard D., Kislyuk, Andrey O., Spittle, Kristi E., Boitano, Matthew, Fomenkov, Alexey, Roberts, Richard J., Korlach, Jonas
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Methods Online
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287169/
https://ncbi.nlm.nih.gov/pubmed/22156058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1146
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