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Structural and functional diversity among Type III restriction-modification systems that confer host DNA protection via methylation of the N4 atom of cytosine

We report a new subgroup of Type III Restriction-Modification systems that use m4C methylation for host protection. Recognition specificities for six such systems, each recognizing a novel motif, have been determined using single molecule real-time DNA sequencing. In contrast to all previously chara...

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Pubblicato in:PLoS One
Autori principali: Murray, Iain A., Luyten, Yvette A., Fomenkov, Alexey, Dai, Nan, Corrêa, Ivan R., Farmerie, William G., Clark, Tyson A., Korlach, Jonas, Morgan, Richard D., Roberts, Richard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259958/
https://ncbi.nlm.nih.gov/pubmed/34228724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0253267
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