Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine

We describe strand-specific, base-resolution detection of 5-hydroxymethylcytosine (5-hmC) in genomic DNA with single-molecule sensitivity, combining a bioorthogonal, selective chemical labeling method of 5-hmC with single-molecule, real-time (SMRT) DNA sequencing. The chemical labeling not only allo...

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Hoofdauteurs: Song, Chun-Xiao, Clark, Tyson A, Lu, Xing-Yu, Kislyuk, Andrey, Dai, Qing, Turner, Stephen W, He, Chuan, Korlach, Jonas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646335/
https://ncbi.nlm.nih.gov/pubmed/22101853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1779
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