Analysis of RNA base modification and structural rearrangement by single-molecule real-time detection of reverse transcription

BACKGROUND: Zero-mode waveguides (ZMWs) are photonic nanostructures that create highly confined optical observation volumes, thereby allowing single-molecule-resolved biophysical studies at relatively high concentrations of fluorescent molecules. This principle has been successfully applied in singl...

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Hlavní autoři: Vilfan, Igor D, Tsai, Yu-Chih, Clark, Tyson A, Wegener, Jeffrey, Dai, Qing, Yi, Chengqi, Pan, Tao, Turner, Stephen W, Korlach, Jonas
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Methodology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623877/
https://ncbi.nlm.nih.gov/pubmed/23552456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3155-11-8
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