Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis

The drivers of abnormal DNA methylation in human cancers include widespread aberrant splicing of the DNMT3B gene, producing abnormal transcripts that encode truncated proteins that may act as dominant negative isoforms. To test whether reduced Dnmt3b dosage can alter tumorigenesis, we bred Dnmt3b(+/...

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Bibliografiska uppgifter
Huvudupphovsmän: Vasanthakumar, Aparna, Lepore, Janet B., Zegarek, Matthew H., Kocherginsky, Masha, Singh, Mahi, Davis, Elizabeth M., Link, Petra A., Anastasi, John, Le Beau, Michelle M., Karpf, Adam R., Godley, Lucy A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2013
Ämnen:
Lymphoid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596965/
https://ncbi.nlm.nih.gov/pubmed/23315164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-421065
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