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Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
The drivers of abnormal DNA methylation in human cancers include widespread aberrant splicing of the DNMT3B gene, producing abnormal transcripts that encode truncated proteins that may act as dominant negative isoforms. To test whether reduced Dnmt3b dosage can alter tumorigenesis, we bred Dnmt3b(+/...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3596965/ https://ncbi.nlm.nih.gov/pubmed/23315164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-421065 |
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