Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis

The drivers of abnormal DNA methylation in human cancers include widespread aberrant splicing of the DNMT3B gene, producing abnormal transcripts that encode truncated proteins that may act as dominant negative isoforms. To test whether reduced Dnmt3b dosage can alter tumorigenesis, we bred Dnmt3b(+/...

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Hauptverfasser: Vasanthakumar, Aparna, Lepore, Janet B., Zegarek, Matthew H., Kocherginsky, Masha, Singh, Mahi, Davis, Elizabeth M., Link, Petra A., Anastasi, John, Le Beau, Michelle M., Karpf, Adam R., Godley, Lucy A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596965/
https://ncbi.nlm.nih.gov/pubmed/23315164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-04-421065
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