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Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy
Cardiomyopathy is associated with cardiac Na(+) channel downregulation that may contribute to arrhythmias. Previously, we have shown that elevated intracellular NADH causes a decrease in cardiac Na(+) current (I(Na)) signaled by an increase in mitochondrial reactive oxygen species (ROS). In this stu...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3595554/ https://ncbi.nlm.nih.gov/pubmed/23123323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.10.011 |
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