Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy

Cardiomyopathy is associated with cardiac Na(+) channel downregulation that may contribute to arrhythmias. Previously, we have shown that elevated intracellular NADH causes a decrease in cardiac Na(+) current (I(Na)) signaled by an increase in mitochondrial reactive oxygen species (ROS). In this stu...

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Autors principals: Liu, Man, Gu, Lianzhi, Sulkin, Matthew S., Liu, Hong, Jeong, Euy-Myoung, Greener, Ian, Xie, An, Efimov, Igor R., Dudley, Samuel C.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595554/
https://ncbi.nlm.nih.gov/pubmed/23123323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.10.011
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