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Abnormal Sodium Channel mRNA Splicing in Hypertrophic Cardiomyopathy
BACKGROUND: Our previous studies showed that in ischemic and nonischemic heart failure (HF), the voltage-gated cardiac Na(+) channel α subunit (SCN5A) mRNA is abnormally spliced to produce two truncated transcript variants (E28C and D) that activate the unfolded protein response (UPR). We tested whe...
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| Publicado no: | Int J Cardiol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5681396/ https://ncbi.nlm.nih.gov/pubmed/28916354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2017.08.071 |
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