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Abnormal Sodium Channel mRNA Splicing in Hypertrophic Cardiomyopathy

BACKGROUND: Our previous studies showed that in ischemic and nonischemic heart failure (HF), the voltage-gated cardiac Na(+) channel α subunit (SCN5A) mRNA is abnormally spliced to produce two truncated transcript variants (E28C and D) that activate the unfolded protein response (UPR). We tested whe...

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Detalhes bibliográficos
Publicado no:Int J Cardiol
Main Authors: Noyes, Adam M., Zhou, Anyu, Gao, Ge, Gu, Lianzhi, Day, Sharlene, Wasserstrom, J. Andrew, Dudley, Samuel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681396/
https://ncbi.nlm.nih.gov/pubmed/28916354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2017.08.071
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