The Role of RBM25/LUC7L3 in Abnormal Cardiac Sodium Channel Splicing Regulation in Human Heart Failure

BACKGROUND: Human heart failure (HF) is associated with decreased cardiac voltage-gated Na(+) channel current (encoded by SCN5A), and the changes have been implicated in the increased risk of sudden death in HF. Nevertheless, the mechanism of SCN5A downregulation is unclear. A number of human diseas...

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Autors principals: Gao, Ge, Xie, An, Huang, Shu-Ching, Zhou, Anyu, Zhang, Jianhua, Herman, Amanda M., Ghassemzadeh, Sassan, Jeong, Euy-Myoung, Kasturirangan, Srinivasan, Raicu, Mihai, Sobieski, Michael A., Bhat, Geetha, Tatooles, Antone, Benz, Edward J., Kamp, Timothy J., Dudley, Samuel C.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172047/
https://ncbi.nlm.nih.gov/pubmed/21859973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.044495
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