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Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx

The activation and stabilization of the p53 protein play a major role in the DNA damage response. Protein levels of p53 are tightly controlled by transcriptional regulation and a number of positive and negative posttranslational modifiers, including kinases, phosphatases, E3 ubiquitin ligases, deubi...

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Библиографические подробности
Главные авторы: Lu, Zengxin, Wan, Guohui, Guo, Huarong, Zhang, Xinna, Lu, Xiongbin
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595384/
https://ncbi.nlm.nih.gov/pubmed/23277204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2012.12.014
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