USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

Tumour suppressor p53 levels in the cell are tightly regulated by controlled degradation through ubiquitin ligases including Mdm2, COP1, Pirh2, and ARF-BP1. The ubiquitination process is reversible via deubiquitinating enzymes, such as ubiquitin-specific peptidases (USPs). In this study, we identifi...

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Autors principals: Zhang, Xinna, Berger, Franklin G, Yang, Jianhua, Lu, Xiongbin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117646/
https://ncbi.nlm.nih.gov/pubmed/21522127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.125
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