USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2

Histone deacetylases (HDACs) are major epigenetic modulators involved in a broad spectrum of human diseases including cancers. As HDACs are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. In this study, we show that ubiquitin-specific peptidase 4...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Li, Z, Hao, Q, Luo, J, Xiong, J, Zhang, S, Wang, T, Bai, L, Wang, W, Chen, M, Gu, L, Lv, K, Chen, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895393/
https://ncbi.nlm.nih.gov/pubmed/26411366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.349
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