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Oncogenic Wip1 Phosphatase is Inhibited by miR-16 in the DNA Damage Signaling Pathway
Wildtype p53-induced phosphatase 1 (Wip1) was identified as an oncogene amplified and overexpressed in a number of human cancers. Recent evidence suggested that Wip1 is a critical inhibitor in the ATM/ATR -p53 DNA damage signaling pathway. Wip1 dephosphorylates several key DNA damage-responsive prot...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2940956/ https://ncbi.nlm.nih.gov/pubmed/20668064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0697 |
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