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AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX–MDM2 complex

Deregulation of the tyrosine kinase signalling is often associated with tumour progression and drug resistance, but its underlying mechanisms are only partly understood. In this study, we investigated the effects of the receptor tyrosine kinase AXL on the stability of the MDMX–MDM2 heterocomplex and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Mol Cell Biol
Prif Awduron: de Polo, Anna, Luo, Zhongling, Gerarduzzi, Casimiro, Chen, Xiang, Little, John B., Yuan, Zhi-Min
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907837/
https://ncbi.nlm.nih.gov/pubmed/27927748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjw045
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