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AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX–MDM2 complex

Deregulation of the tyrosine kinase signalling is often associated with tumour progression and drug resistance, but its underlying mechanisms are only partly understood. In this study, we investigated the effects of the receptor tyrosine kinase AXL on the stability of the MDMX–MDM2 heterocomplex and...

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Dades bibliogràfiques
Publicat a:J Mol Cell Biol
Autors principals: de Polo, Anna, Luo, Zhongling, Gerarduzzi, Casimiro, Chen, Xiang, Little, John B., Yuan, Zhi-Min
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907837/
https://ncbi.nlm.nih.gov/pubmed/27927748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjw045
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