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AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX–MDM2 complex

Deregulation of the tyrosine kinase signalling is often associated with tumour progression and drug resistance, but its underlying mechanisms are only partly understood. In this study, we investigated the effects of the receptor tyrosine kinase AXL on the stability of the MDMX–MDM2 heterocomplex and...

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Detalhes bibliográficos
Publicado no:J Mol Cell Biol
Main Authors: de Polo, Anna, Luo, Zhongling, Gerarduzzi, Casimiro, Chen, Xiang, Little, John B., Yuan, Zhi-Min
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907837/
https://ncbi.nlm.nih.gov/pubmed/27927748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjw045
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