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AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX–MDM2 complex
Deregulation of the tyrosine kinase signalling is often associated with tumour progression and drug resistance, but its underlying mechanisms are only partly understood. In this study, we investigated the effects of the receptor tyrosine kinase AXL on the stability of the MDMX–MDM2 heterocomplex and...
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| Publicado en: | J Mol Cell Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5907837/ https://ncbi.nlm.nih.gov/pubmed/27927748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mjw045 |
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