Topoisomerase 1-mediated Removal of Ribonucleotides from Nascent Leading Strand DNA

RNase H2-dependent Ribonucleotide Excision Repair (RER) removes ribonucleotides incorporated during DNA replication. When RER is defective, ribonucleotides in the nascent leading strand of the yeast genome are associated with replication stress and genome instability. Here we provide evidence that t...

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Bibliografiske detaljer
Main Authors: Williams, Jessica S., Smith, Dana J., Marjavaara, Lisette, Lujan, Scott A., Chabes, Andrei, Kunkel, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595360/
https://ncbi.nlm.nih.gov/pubmed/23375499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.12.021
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