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Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific
Ribonucleotides incorporated during nuclear DNA replication are removed by RNase H2-dependent ribonucleotide excision repair (RER). When RER is defective, topoisomerase 1 (Top1) incises the DNA at unrepaired ribonucleotides, initiating their removal but accompanied by slow growth, replicative stress...
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| I publikationen: | Nat Struct Mol Biol |
|---|---|
| Huvudupphovsmän: | , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4835660/ https://ncbi.nlm.nih.gov/pubmed/25751426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2989 |
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