Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific

Ribonucleotides incorporated during nuclear DNA replication are removed by RNase H2-dependent ribonucleotide excision repair (RER). When RER is defective, topoisomerase 1 (Top1) incises the DNA at unrepaired ribonucleotides, initiating their removal but accompanied by slow growth, replicative stress...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Williams, Jessica S., Clausen, Anders R., Lujan, Scott A., Marjavaara, Lisette, Clark, Alan B., Burgers, Peter M., Chabes, Andrei, Kunkel, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835660/
https://ncbi.nlm.nih.gov/pubmed/25751426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2989
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