IL-12 Enhances the Antitumor Actions of Trastuzumab via NK Cell IFN-γ Production

The antitumor effects of therapeutic mAbs may depend on immune effector cells that express FcRs for IgG. IL-12 is a cytokine that stimulates IFN-γ production from NK cells and T cells. We hypothesized that coadministration of IL-12 with a murine anti-HER2/neu mAb (4D5) would enhance the FcR-dependen...

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Hauptverfasser: Jaime-Ramirez, Alena Cristina, Mundy-Bosse, Bethany L., Kondadasula, SriVidya, Jones, Natalie B., Roda, Julie M., Mani, Aruna, Parihar, Robin, Karpa, Volodymyr, Papenfuss, Tracey L., LaPerle, Krista M., Biller, Elizabeth, Lehman, Amy, Chaudhury, Abhik Ray, Jarjoura, David, Burry, Richard W., Carson, William E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593307/
https://ncbi.nlm.nih.gov/pubmed/21321106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000328
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