IL-12 Enhances the Antitumor Actions of Trastuzumab via NK Cell IFN-γ Production

The antitumor effects of therapeutic mAbs may depend on immune effector cells that express FcRs for IgG. IL-12 is a cytokine that stimulates IFN-γ production from NK cells and T cells. We hypothesized that coadministration of IL-12 with a murine anti-HER2/neu mAb (4D5) would enhance the FcR-dependen...

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Autori principali: Jaime-Ramirez, Alena Cristina, Mundy-Bosse, Bethany L., Kondadasula, SriVidya, Jones, Natalie B., Roda, Julie M., Mani, Aruna, Parihar, Robin, Karpa, Volodymyr, Papenfuss, Tracey L., LaPerle, Krista M., Biller, Elizabeth, Lehman, Amy, Chaudhury, Abhik Ray, Jarjoura, David, Burry, Richard W., Carson, William E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593307/
https://ncbi.nlm.nih.gov/pubmed/21321106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000328
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