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Enhanced anti-tumor activity of interferon-alpha in SOCS1-deficient mice is mediated by CD4(+) and CD8(+) T cells

Interferon-alpha (IFN-α) is an immunomodulatory cytokine that is used clinically for the treatment of melanoma in the adjuvant setting. The cellular actions of IFN-α are regulated by the suppressors of cytokine signaling (SOCS) family of proteins. We hypothesized that the anti-tumor activity of exog...

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Bibliografiske detaljer
Main Authors: Guenterberg, Kristan D., Lesinski, Gregory B., Mundy-Bosse, Bethany L., Karpa, Volodymyr I., Jaime-Ramirez, Alena Cristina, Wei, Lai, Carson, William E.
Format: Artigo
Sprog:Inglês
Udgivet: Springer-Verlag 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521522/
https://ncbi.nlm.nih.gov/pubmed/21604070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-1034-2
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