Colocalization of the IL-12 receptor and FcγRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-γ

Natural killer (NK) cells express an activating receptor for the Fc portion of IgG (FcγRIIIa) that mediates interferon (IFN)–γ production in response to antibody (Ab)–coated targets. We have previously demonstrated that NK cells activated with interleukin-12 (IL-12) in the presence of immobilized Ig...

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Detalhes bibliográficos
Main Authors: Kondadasula, Sri Vidya, Roda, Julie M., Parihar, Robin, Yu, Jianhua, Lehman, Amy, Caligiuri, Michael A., Tridandapani, Susheela, Burry, Richard W., Carson, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2288725/
https://ncbi.nlm.nih.gov/pubmed/18174382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-068908
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