Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the FcγRIIIa-158 V/V and V/F polymorphism

The presence of valine (V) at position 158 of FcγRllla (CD16) is known to improve clinical response to rituximab in indolent non-Hodgkin lymphoma (NHL). Little is known about the basic mechanisms for this observation. We examined natural killer (NK) cells from healthy donors representing the FcγRIII...

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Detalhes bibliográficos
Main Authors: Hatjiharissi, Evdoxia, Xu, Lian, Santos, Daniel Ditzel, Hunter, Zachary R., Ciccarelli, Bryan T., Verselis, Sigitas, Modica, Michael, Cao, Yang, Manning, Robert J., Leleu, Xavier, Dimmock, Elizabeth A., Kortsaris, Alexandros, Mitsiades, Constantine, Anderson, Kenneth C., Fox, Edward A., Treon, Steven P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988936/
https://ncbi.nlm.nih.gov/pubmed/17475906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-070656
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