IL-12 Enhances the Antitumor Actions of Trastuzumab via NK Cell IFN-γ Production

The antitumor effects of therapeutic mAbs may depend on immune effector cells that express FcRs for IgG. IL-12 is a cytokine that stimulates IFN-γ production from NK cells and T cells. We hypothesized that coadministration of IL-12 with a murine anti-HER2/neu mAb (4D5) would enhance the FcR-dependen...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Jaime-Ramirez, Alena Cristina, Mundy-Bosse, Bethany L., Kondadasula, SriVidya, Jones, Natalie B., Roda, Julie M., Mani, Aruna, Parihar, Robin, Karpa, Volodymyr, Papenfuss, Tracey L., LaPerle, Krista M., Biller, Elizabeth, Lehman, Amy, Chaudhury, Abhik Ray, Jarjoura, David, Burry, Richard W., Carson, William E.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2011
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593307/
https://ncbi.nlm.nih.gov/pubmed/21321106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1000328
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