TRIPTOLIDE INDUCES CELL DEATH IN PANCREATIC CANCER CELLS BY APOPTOTIC AND AUTOPHAGIC PATHWAYS

BACKGROUND & AIMS: Pancreatic adenocarcinoma, among the most lethal human malignancies, is resistant to current chemotherapies. We have previously shown that triptolide inhibits the growth of pancreatic cancer cells in vitro and prevents tumor growth in vivo. This study investigates the mechanis...

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Hlavní autoři: Mujumdar, Nameeta, MacKenzie, Tiffany, Dudeja, Vikas, Chugh, Rohit, Antonoff, Mara, Borja-Cacho, Daniel, Sangwan, Veena, Dawra, Rajinder, Vickers, Selwyn M., Saluja, Ashok K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3587769/
https://ncbi.nlm.nih.gov/pubmed/20434451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.04.046
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