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Role of Hsp-70 in Triptolide-Mediated Cell Death of Neuroblastoma

BACKGROUND: Our recent work demonstrated that treatment of neurobastoma with triptolide causes apoptotic cell death in vitro and decreased tumor size in vivo. Triptolide therapy has been associated with reduced expression of Hsp-70, suggesting a mechanism of cell killing involving Hsp-70 inhibition....

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Detalhes bibliográficos
Main Authors: Antonoff, Mara B., Chugh, Rohit, Skube, Steven J., Dudeja, Vikas, Borja-Cacho, Daniel, Clawson, Kimberly A., Vickers, Selwyn M., Saluja, Ashok K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142566/
https://ncbi.nlm.nih.gov/pubmed/20638672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2010.04.047
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