Role of Hsp-70 in Triptolide-Mediated Cell Death of Neuroblastoma

BACKGROUND: Our recent work demonstrated that treatment of neurobastoma with triptolide causes apoptotic cell death in vitro and decreased tumor size in vivo. Triptolide therapy has been associated with reduced expression of Hsp-70, suggesting a mechanism of cell killing involving Hsp-70 inhibition....

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Bibliografiske detaljer
Main Authors: Antonoff, Mara B., Chugh, Rohit, Skube, Steven J., Dudeja, Vikas, Borja-Cacho, Daniel, Clawson, Kimberly A., Vickers, Selwyn M., Saluja, Ashok K.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142566/
https://ncbi.nlm.nih.gov/pubmed/20638672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2010.04.047
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