Role of Hsp-70 in Triptolide-Mediated Cell Death of Neuroblastoma

BACKGROUND: Our recent work demonstrated that treatment of neurobastoma with triptolide causes apoptotic cell death in vitro and decreased tumor size in vivo. Triptolide therapy has been associated with reduced expression of Hsp-70, suggesting a mechanism of cell killing involving Hsp-70 inhibition....

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Autores principales: Antonoff, Mara B., Chugh, Rohit, Skube, Steven J., Dudeja, Vikas, Borja-Cacho, Daniel, Clawson, Kimberly A., Vickers, Selwyn M., Saluja, Ashok K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142566/
https://ncbi.nlm.nih.gov/pubmed/20638672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2010.04.047
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