Convergent Replication of Mouse Synthetic Prion Strains

Prion diseases are neurodegenerative disorders characterized by the aberrant folding of endogenous proteins into self-propagating pathogenic conformers. Prion disease can be initiated in animal models by inoculation with amyloid fibrils formed from bacterially derived recombinant prion protein. The...

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Bibliographische Detailangaben
Hauptverfasser: Ghaemmaghami, Sina, Colby, David W., Nguyen, Hoang-Oanh B., Hayashi, Shigenari, Oehler, Abby, DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2013
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586687/
https://ncbi.nlm.nih.gov/pubmed/23438476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.11.038
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