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Valproic acid overcomes hypoxia-induced resistance to apoptosis

Valproic acid (VPA), a histone deacetylase inhibitor (HDACi), has been shown to be an effective tool in cancer treatment. Although its ability to induce apoptosis has been described in many cancer types, the data come from experiments performed in normoxic (21% O(2)) conditions only. Therefore, we q...

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Hlavní autoři: CIPRO, ŠIMON, HŘEBAČKOVÁ, JANA, HRABĚTA, JAN, POLJAKOVÁ, JITKA, ECKSCHLAGER, TOMÁŠ
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583540/
https://ncbi.nlm.nih.gov/pubmed/22159638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2011.1577
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