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The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells

Neuroblastoma (NBL) originates from undifferentiated cells of the sympathetic nervous system. Chemotherapy is judged to be suitable for successful treatment of this disease. Here, the influence of histone deacetylase (HDAC) inhibitor valproate (VPA) combined with DNA-damaging chemotherapeutic, ellip...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Cerna, Tereza, Hrabeta, Jan, Eckschlager, Tomas, Frei, Eva, Schmeiser, Heinz H., Arlt, Volker M., Stiborová, Marie
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796113/
https://ncbi.nlm.nih.gov/pubmed/29304031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19010164
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