Cytochrome b(5) plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine

ABSTRACT: Ellipticine is an anticancer agent that forms covalent DNA adducts after enzymatic activation by cytochrome P450 (CYP) enzymes, mainly by CYP3A4. This process is one of the most important ellipticine DNA-damaging mechanisms for its antitumor action. Here, we investigated the efficiencies o...

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Vydáno v:Monatsh Chem
Hlavní autoři: Stiborová, Marie, Indra, Radek, Frei, Eva, Kopečková, Kateřina, Schmeiser, Heinz H., Eckschlager, Tomáš, Adam, Vojtěch, Heger, Zbyněk, Arlt, Volker M., Martínek, Václav
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Vienna 2017
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653753/
https://ncbi.nlm.nih.gov/pubmed/29104319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-017-1986-9
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