Cytochrome b(5) plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine

ABSTRACT: Ellipticine is an anticancer agent that forms covalent DNA adducts after enzymatic activation by cytochrome P450 (CYP) enzymes, mainly by CYP3A4. This process is one of the most important ellipticine DNA-damaging mechanisms for its antitumor action. Here, we investigated the efficiencies o...

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Detalhes bibliográficos
Publicado no:Monatsh Chem
Main Authors: Stiborová, Marie, Indra, Radek, Frei, Eva, Kopečková, Kateřina, Schmeiser, Heinz H., Eckschlager, Tomáš, Adam, Vojtěch, Heger, Zbyněk, Arlt, Volker M., Martínek, Václav
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Vienna 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653753/
https://ncbi.nlm.nih.gov/pubmed/29104319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-017-1986-9
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