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Valproic Acid Increases CD133 Positive Cells that Show Low Sensitivity to Cytostatics in Neuroblastoma

Valproic acid (VPA) is a well-known antiepileptic drug that exhibits antitumor activities through its action as a histone deacetylase inhibitor. CD133 is considered to be a cancer stem cell marker in several tumors including neuroblastoma. CD133 transcription is strictly regulated by epigenetic modi...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Khalil, Mohamed Ashraf, Hraběta, Jan, Groh, Tomáš, Procházka, Pavel, Doktorová, Helena, Eckschlager, Tomáš
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023141/
https://ncbi.nlm.nih.gov/pubmed/27627801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162916
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