Acamprosate suppresses magnetic resonance spectroscopy measures of central glutamate in detoxified alcoholics: A randomized controlled experimental medicine study

CONTEXT: Acamprosate is approved for treatment of alcoholism, but its mechanism of action remains unclear. Animal studies suggest that a persistent hyperglutamatergic state contributes to the pathophysiology of alcoholism, and that acamprosate may exert its actions by intervening in this process. Hu...

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Main Authors: Umhau, John C., Momenan, Reza, Schwandt, Melanie L., Singley, Erick, Lifshitz, Mariel, Doty, Linda, Adams, Lauren J., Vengeliene, Valentina, Spanagel, Rainer, Zhang, Yan, Shen, Jun, George, David T., Hommer, Daniel, Heilig, Markus
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583213/
https://ncbi.nlm.nih.gov/pubmed/20921123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archgenpsychiatry.2010.125
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