Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST

A hyperglutamatergic state has been hypothesized to drive escalation of alcohol intake. This hypothesis predicts that an impairment of glutamate clearance through inactivation of the astrocytic glutamate transporter, GLAST (EAAT1), will result in escalation of alcohol consumption. Here, we used mice...

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Autori principali: Karlsson, Rose-Marie, Adermark, Louise, Molander, Anna, Perreau-Lenz, Stephanie, Singley, Erick, Solomon, Matthew, Holmes, Andrew, Tanaka, Kohichi, Lovinger, David M., Spanagel, Rainer, Heilig, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372600/
https://ncbi.nlm.nih.gov/pubmed/22342743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.01.027
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